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啟發可持續的科研革新文化。

突破科研界限,追求新發現及建立嶄新的研究模式。

關於理學院
理學院致力發展最尖端的科研項目,力求取得突破性的研究成果,建立最新的科研典範。
在教學方面,全面而高質素的課程特別著重培養學生的恒毅力、好奇心和創意…
理學院致力營造一個富活力的學習環境,並著重學術成就、創新及合作。
王殷厚
理學院院長
活動
其他活動形式 | 2024年07月02日
2024 Summer Research Program
The Summer Research Program is designed for outstanding end-of-year 3 undergraduate students who are interested in pursuing research postgraduate study in the School of Science. This program offers participants with the unique opportunity to immerse themselves in the research life at HKUST campus and work with faculty mentors from our School in conducting research projects in an interactive environment. Date: 2 July – 6 August, 2024     Eligibility: Undergraduate students majoring in science and related programs, who have completed 3 years of study (out of a 4-year bachelor program) and have attained a GPA of 3.2 out of 4.0 (or 80%) or higher. A subsidy of around HK$10,000 will be provided to cover the on-campus student hostel fee and other local expenses. To enroll in this Summer Research Program, participants are required to pay the summer internship application fee, insurance, visa fee and a 1-credit tuition fee in advance (approximately HK$3,300). Additionally, participants are responsible for applying for a visa (which may take 10-12 weeks) and covering their own transportation costs to and from Hong Kong. Application Procedures: Department of Ocean Science: Fill in the application form and send it together with your academic transcript and resume to the department (ocescamp@ust.hk) Division of Life Science: Submit online application to the division directly Department of Physics: Submit online application to the division directly Department of Chemistry: Submit online application to the department directly Department of Mathematics: Submit online application to the department directly   The review of applications will be conducted by the respective Division/Department. Successful applicants will be notified by the Division/Department as soon as the application is closed. After receiving the Division/Department’s confirmation: (For successful applicants only) Submit online Visiting Interns application to the Undergraduate Recruitment and Admissions Office (https://join.ust.hk/admissions/visiting/) Application deadline: 17 March, 2024
研討會, 演講, 講座 | 2024年04月26日
IAS / School of Science Joint Lecture - Molecular Basis of Wnt Biogenesis, Secretion and Ligand Specific Signaling
Abstract Wnt signaling is essential to regulate embryonic development and adult tissue homeostasis. Aberrant Wnt signaling is associated with cancers. The ER-resident membrane-bound O-acyltransferase Porcupine (PORCN) transfers a palmitoleoyl moiety to Wnt. This lipidation is indispensable for Wnt binding to its receptor Frizzled, thereby initiating signaling. Once modified, Wnt is transported to the cell surface via binding its transporter Wntless. In the lecture, the speaker will report four cryo-EM structures of human PORCN in the distinct states. Moreover, the speaker and his group’s recent cryo-EM and mass spectrometry studies have identified a Wnt chaperone that is essential for Wnt transfer from PORCN to Wntless and its secretion. Their structural and functional analyses with molecular-dynamics simulations demonstrate that a phospholipid in the core of Wnt-bound Wntless regulates the association and dissociation between Wnt and Wntless, suggesting a lipid-mediated Wnt secretion mechanism. Together, their works provide a mechanism of Wnt production and advance the development of PORCN inhibitors for cancer treatment. About the Speaker Prof. LI Xiaochun received his BS in Chemistry and Biology in 2008 and finished his PhD training in Structural Biology in 2012, both at Tsinghua University. His postdoctoral studies as a Life Science Research Foundation Fellow were conducted at the Rockefeller University. In 2017, he joined the faculty at the University of Texas (UT) Southwestern Medical Center. He is currently an Associate Professor and a Rita C. and William P. Clements, Jr. Scholar in Biomedical Research in the Department of Molecular Genetics and the Department of Biophysics at UT Southwestern Medical Center. Prof. Li’s research focuses on membrane proteins in cholesterol biogenesis, transport, and signaling using multiple approaches from protein engineering to x-ray crystallography and cryo-EM. He is the recipient of 2019 Damon Runyon-Rachleff Innovation Award, 2023 American Heart Association Established Investigator Award, and 2023 G. Harold and Leila Y. Mathers Foundation Award. For Attendees' Attention Seating is on a first come, first served basis.
研討會, 演講, 講座 | 2024年04月18日
IAS / School of Science Joint Lecture - Understanding the Roles of Transposable Elements in the Human Genome
Abstract Transposable elements (TEs) have expanded the binding repertoire of many transcription factors and, through this process, have been co-opted in different transcriptional networks. In this lecture, the speaker will present on three recent projects that explore the role of TEs in the human genome. First, he will discuss the results of a study looking at epigenetic changes following influenza infection in monocyte-derived macrophages extracted from 35 individuals of different ancestry. Specifically, he will show that different TEs families are associated with regions of shared and variable accessibility across individuals upon infection. He will also show that TEs can predict a significant portion of the heterogeneity that his research team observes in the response to infection. Then, he will discuss a study that leveraged a new dataset from the International Human Epigenome Consortium (IHEC) with 5219 ChIP-seq experiments for 6 histone marks across 60 cell types. From this, the speaker will show that TEs have drastically different enrichment levels across marks and tissues. In particular, he will identify over 100 TE-Cell type-histone mark triplets to explore their potential functional relevance. Lastly, he observed that current approaches for classifying and annotating endogenous retroviruses (ERVs) in the human genome have limited resolution and are inaccurate. The speaker will propose a new annotation based on phylogenetic analysis and cross-species conservation that reveals cryptic ERV subfamilies in the primate lineage with distinct epigenetic profiles. With such a refined annotation, it will be possible to better understand the evolution of ERVs in primate genomes and identify new roles for them in their hosts.   About the Speaker Dr. Guillaume BOURQUE is a Professor in the Department of Human Genetics at McGill University, a Canada Research Chair in Computational Genomics and Medicine and the Director of Bioinformatics at the McGill Genome Centre. He leads the Canadian Centre for Computational Genomics and the Epigenomics Mapping Centre at McGill. He is also a Principal Investigator at the Institute for the Advanced Study of Human Biology (ASHBi) of Kyoto University. Dr. Bourque is on the Scientific Steering Committee of the International Human Epigenome Consortium (IHEC) and on the Steering Committee of the Global Alliance for Genomics and Health (GA4GH). He leads a project called the Pan-Canadian Genome Library, which will allow for easier analysis and sharing of genomic data across the country. His research interests are in comparative and functional genomics with a special emphasis on applications of next-generation sequencing technologies and transposable elements.   For Attendees' Attention Seating is on a first come, first served basis.
No. 26
Science Focus
Science Focus由理學院本科生在教職員的指導下編寫及設計。旨在透過有趣的科研文章以啟發及培育學生於科學及科研發現的興趣。
就讀
理學院
本科生
課程
注入新元素,使課程更加多樣化,並增加跨學科課程,培養學生獨立探索的能力。
研究生
課程
緊貼最新的科技發展,為學生提供具備啟發性思維的訓練。
學術單位
化學系
生命科學部
數學系
海洋科學系
物理系
化學系
化學系的教職員既充滿朝氣,亦具備群策群力的團隊精神。他們活躍於化學研究的各個領域,其研究成果更獲得國際認同。
生命科學部
生命科學部旨在促進生物科學的科研和教育之發展。
數學系
數學系的兩大基柱為追求卓越的研究成果及承諾提供高效優質的教學課程。
海洋科學系
本系旨在帶領各方認識不同領域的海洋科技,包括有關海洋保育,氣候變化,海洋資源管理,社會經濟及可持續發展的基礎概念和實踐。
物理系
物理系的使命乃由教學、科研及創新這鐵三角組成。
科目研究
突破科研界限,追求新發現及建立嶄新的研究模式。