High dimensional categorical data are routinely collected in biomedical and social sciences. It is of great importance to build interpretable parsimonious models that perform dimension reduction and uncover meaningful latent structures from such discrete data. Identifiability is a fundamental requirement for valid modeling and inference in such scenarios, yet is challenging to address when there are complex latent structures. In this article, we propose a class of identifiable multilayer (potentially deep) discrete latent structure models for discrete data, termed Bayesian pyramids. We establish the identifiability of Bayesian pyramids by developing novel transparent conditions on the pyramid-shaped deep latent directed graph. The proposed identifiability conditions can ensure Bayesian posterior consistency under suitable priors. As an illustration, we consider the two-latent-layer model and propose a Bayesian shrinkage estimation approach. Simulation results for this model corroborate the identifiability and estimability of model parameters. Applications of the methodology to DNA nucleotide sequence data uncover useful discrete latent features that are highly predictive of sequence types. The proposed framework provides a recipe for interpretable unsupervised learning of discrete data, and can be a useful alternative to popular machine learning methods.

3月25日
10:00am - 11:00am
地点
https://hkust.zoom.us/j/6827297694 (Passcode: 7436)
讲者/表演者
Prof. Yuqi GU
Columbia University
主办单位
Department of Mathematics
联系方法
付款详情
对象
Alumni, Faculty and staff, PG students, UG students
语言
英语
其他活动
3月24日
研讨会, 演讲, 讲座
IAS / School of Science Joint Lecture - Pushing the Limit of Nonlinear Vibrational Spectroscopy for Molecular Surfaces/Interfaces Studies
Abstract Surfaces and interfaces are ubiquitous in Nature. Sum-frequency generation vibrational spectroscopy (SFG-VS) is a powerful surface/interface selective and sub-monolayer sensitive spect...
11月22日
研讨会, 演讲, 讲座
IAS / School of Science Joint Lecture - Leveraging Protein Dynamics Memory with Machine Learning to Advance Drug Design: From Antibiotics to Targeted Protein Degradation
Abstract Protein dynamics are fundamental to protein function and encode complex biomolecular mechanisms. Although Markov state models have made it possible to capture long-timescale protein co...