We develop modeling and analysis approaches for quantifying the in vivo evolution of clonal blood cell populations. A stochastic birth-death-immigration (BDI) model is used to describe experiments that measure hematopoietic stem cell tags and T cell immunotypes. We investigate a number of important processes that affect the predictions of the BDI model, including stochasticity, subsampling, regulation, and heterogeneity in rates. Using variations of this underlying mathematical framework, we estimate the effective proliferative potential of progenitor cells, the heterogeneity of naive T cell output by the thymus, and the heterogeneity of their homeostatic proliferation rates.
12月3日
3:00pm - 4:00pm
地點
LTF, Academic Building
講者/表演者
Prof. Tom CHOU
University of California, Los Angeles
主辦單位
Department of Mathematics
聯絡方法
mathseminar@ust.hk
付款詳情
對象
Alumni, Faculty and Staff, PG Students, UG Students
語言
英語
其他活動
10月10日
研討會, 演講, 講座
IAS / School of Science Joint Lecture - Use of Large Animal Models to Investigate Brain Diseases
Abstract Genetically modified animal models have been extensively used to investigate the pathogenesis of age-dependent neurodegenerative diseases, such as Alzheimer (AD), Parkinson (PD), Hunti...
7月14日
研討會, 演講, 講座
IAS / School of Science Joint Lecture - Boron Clusters
Abstract The study of carbon clusters led to the discoveries of fullerenes, carbon nanotubes, and graphene. Are there other elements that can form similar nanostructures? To answer this questio...