We develop modeling and analysis approaches for quantifying the in vivo evolution of clonal blood cell populations. A stochastic birth-death-immigration (BDI) model is used to describe experiments that measure hematopoietic stem cell tags and T cell immunotypes. We investigate a number of important processes that affect the predictions of the BDI model, including stochasticity, subsampling, regulation, and heterogeneity in rates. Using variations of this underlying mathematical framework, we estimate the effective proliferative potential of progenitor cells, the heterogeneity of naive T cell output by the thymus, and the heterogeneity of their homeostatic proliferation rates.
3 Dec 2019
3:00pm - 4:00pm
Where
LTF, Academic Building
Speakers/Performers
Prof. Tom CHOU
University of California, Los Angeles
Organizer(S)
Department of Mathematics
Contact/Enquiries
mathseminar@ust.hk
Payment Details
Audience
Alumni, Faculty and Staff, PG Students, UG Students
Language(s)
English
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