A research led by Hong Kong University of Science and Technology (HKUST) has revealed a novel mechanism that regulates secretion of sonic hedgehog (Shh), a key signaling molecular that plays an important role in cancer progression, in mammals, opening the door to novel therapeutic strategies for cancer induced by the hedgehog signaling pathway.

The hedgehog (Hh) signaling pathway is instrumental in regulating embryonic patterning and facilitating the development of the central nervous system and organs of the human body. Read More... 


Figure 1

A diagram demonstrating how hedgehog molecules are secreted from the producing cells and received by the target cells to induce the signal transduction pathway in target cells.