IAS / School of Science Joint Lecture - Human B Cell Receptor-Epitope Selection for Pan-Sarbecovirus Neutralization
Abstract
The induction of broadly neutralizing antibodies (bnAbs) against viruses requires the specific activation of human B cell receptors (BCRs) by viral epitopes. Following BCR activation, B cells can undergo germinal center–dependent and –independent pathways to generate both long-term…
MATH - Seminar on Statistics and Data Science - Searching for Interactions in Linear Time
We tackle the problem of variable selection with a focus on discovering interactions between variables. With p variables, there are O(p^k) possible interactions of order k making exhaustive search infeasible.