中樞神經系統一旦受創,例如在脊髓損傷的意外中,傷者很可能會永久喪失感覺或活動能力,當中的關鍵原因,是軸突斷裂後無法再生。目前,醫學界為脊髓損傷患者恢復活動能力的方法非常有限。若要為他們帶來治療希望,其中一個 研究方向,便是要破解令這些受傷軸突再生的方法。了解更多...  

 

A working model of IFNγ-STAT1 signaling promoting axon regeneration in CNS and PNS.

In CNS, such as retinal ganglion cells, IFNγ activates STAT1 in Ptpn2 cKO RGCs. STAT1 then upregulates neuronal cGAS expression. cGAS produces cGAMP and activate STING in neurons. In PNS, such as dorsal root ganglion, axotomy induces IFNγ expression in axons by local translation. And IFNγ activates STAT1-cGAS signaling and cGAMP production in surrounding Schwann cells and blood cells, to promote peripheral axon regeneration.
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