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启发可持续的科研革新文化。

突破科研界限,追求新发现及建立崭新的研究模式。

关于理学院
理学院致力发展最尖端的科研项目,力求取得突破性的研究成果,建立最新的科研典范。
在教学方面,全面而高质素的课程特别着重培养学生的恒毅力、好奇心和创意…
理学院致力营造一个富活力的学习环境,并着重学术成就、创新及合作。
王殷厚
理学院院长
活动
研讨会, 演讲, 讲座 | 2023年11月10日
IAS / School of Science Joint Lecture – Biochemical Mechanisms of Plant NLRs
Abstract Plant nucleotide binding and leucine-rich repeat (NLR) receptors mediate specific recognition of pathogen effectors to trigger defense responses against invading pathogens. NLRs, largely comprised of coiled coli NLRs (CNLs) and toll-interleukin 1 receptor NLRs (TNLs), have a central role in plant immunity. Signaling mechanisms of plant NLRs have remained elusive until recently. Direct or indirect recognition of pathogen effectors induces oligomerization of plant NLRs, forming large protein complexes termed resistosomes. CNL resistosomes function as calcium-permeable channels to initiate NLR-mediated immunity. The channel activity of CNLs is evolutionarily conserved. By contrast, TNL resistosomes are NADase holoenzymes that catalyze production of nucleotide-derived small molecules. Structural and biochemical evidence indicates that these small-molecules act as second messengers to activate assembly and channel activity of resistosomes of helper NLRs, a subgroup of the CNL family. The speaker will present evidence of how plant NLRs assemble resistosomes in response to pathogen effectors and how resistosomes converge on calcium signals.   About the Speaker Prof. CHAI Jijie completed his PhD study in Peking Union Medical College in 1997 and conducted his postdoctoral research in Princeton University from 1999 to 2004. He joined National Institute Biological Sciences (NIBS) in 2004 to establish an independent laboratory there. After his promotion from an assistance to an associate investigator in 2009, he moved to Tsinghua University. In 2017, he made a second move to join University of Cologne in Germany as an Alexander von Humboldt Professor/W3 Professor. In 2023, he relocated to Westlake University as a chair professor. Prof. Chai is a pioneer in the plant immune response and has been engaged In the structural and mechanistic of plant immune receptors for a long time. He has published more than 100 papers, including 28 in top journals like Cell, Nature, and Science. In the plant innate immunity field, Prof. Chai made many fundamental contributions: he coined the concept “resistosome”, discovered a class of second messengers that regulating plant innate immunity, and unravel the underlying molecular mechanism by determining a series of high-resolution structures. His research has filled an existing gap in the plant immune system and shed lights on molecular mechanism of plant response to pathogen attack. Prof. Chai received plenty of prestigious awards, including Max Planck Fellow, Alexander von Humboldt Professional Award, The 2020 CAS Outstanding Scientific and Technological Achievement Award, Top Ten Progresses in Life Sciences in China (2019), Second Prize of National Natural Science (2017), National Outstanding Youth Award (2011), and so on. In addition to making great achievements in research, Prof. Chai is an excellent mentor by supervising more than 50 students and postdocs, including those who have become independent faculties in top universities like USTC, SCU, SJTC.   For Attendees' Attention Seating is on a first come, first served basis.
研讨会, 演讲, 讲座 | 2023年11月07日
IAS / School of Science Joint Lecture - Mechanisms of Selective Protein Secretion
Abstract Secretory and membrane proteins account for a third of the eukaryotic proteome, and play important roles in tissue organization, nutrient uptake and cell-cell communication. To function in these roles, each protein must be correctly folded, post-translationally modified and delivered to the appropriate compartment. The speaker’s long-term aim is to define the mechanisms by which protein synthesis and vesicle formation machineries are tuned to match the specific physiological needs of a cell. In this talk, she will describe the recent work on the mechanisms by which an export receptor, SURF4, bridges interactions between soluble secretory proteins within the lumen of the endoplasmic reticulum (ER) and the vesicle budding machinery that delivers cargo to the Golgi. SURF4 recognizes a hydrophobic sorting motif on its client cargo via a membrane-embedded pocket, and interacts with the SEC24 cargo adaptor component of the COPII budding machinery by multiple cytoplasmic signals. The research team used a small molecule that occludes the site of interaction between SEC24 and SURF4 to show that this drug reduces secretion of a subset of the secretome, raising the exciting possibility that protein secretion can be selectively drugged for therapeutic benefit. About the Speaker Prof. Elizabeth Ann MILLER is one of the leading experts in the field of membrane trafficking, particularly in the area of ER export and the quality control checkpoint during membrane protein biogenesis. She gained her Bachelor's degree in Botany and Zoology at the University of Melbourne, Australia and PhD degree in Cell Biology at La Trobe University, Melbourne, Australia. She worked with the Nobel laureate Prof. Randy SCHEKMAN at the University of California at Berkeley as a postdoc working on molecular mechanisms of cargo sorting at the endoplasmic reticulum. Prof. Miller joined the faculty of Department of Biological Sciences, Columbia University as an Assistant Professor in 2005 and Associate Professor with tenure in 2013. In 2015, she became the Programme Leader of the MRC Laboratory of Molecular Biology. She is currently Professor of Molecular Cell and Developmental Biology at University of Dundee. Prof. Miller's research focuses on understanding the basic mechanisms of secretory protein biogenesis, focusing on protein quality control within the endoplasmic reticulum. Her lab uses the budding yeast as a model system, and has discovered new pathways and dissected mechanisms that may be directly relevant to a number of human diseases, most notably cystic fibrosis and similar diseases of protein misfolding. For Attendees' Attention Seating is on a first come, first served basis.
No. 25
Science Focus
Science Focus由理学院本科生在教职员的指导下编写及设计。旨在透过有趣的科研文章以启发及培育学生于科学及科研发现的兴趣。
就读
理学院
本科生
课程
注入新元素,使课程更加多样化,并增加跨学科课程,培养学生独立探索的能力。
研究生
课程
紧贴最新的科技发展,为学生提供具备启发性思维的训练。
学术单位
化学系
生命科学部
数学系
海洋科学系
物理系
化学系
化学系的教职员既充满朝气,亦具备群策群力的团队精神。他们活跃于化学研究的各个领域,其研究成果更获得国际认同。
生命科学部
生命科学部旨在促进生物科学的科研和教育之发展。
数学系
数学系的两大基柱为追求卓越的研究成果及承诺提供高效优质的教学课程。
海洋科学系
本系旨在带领各方认识不同领域的海洋科技,包括有关海洋保育,气候变化,海洋资源管理,社会经济及可持续发展的基础概念和实践。
物理系
物理系的使命乃由教学、科研及创新这铁三角组成。
科目研究
突破科研界限,追求新发现及建立崭新的研究模式。