8月9日
10:30am - 12:00pm
研討會, 演講, 講座
Speaker: Professor Xin ZHANG
Institution: Department of Chemistry, Pennsylvania State University
Hosted by: Professor Benzhong TANG
Abstract
We are fosucsed on protein misfolding and aggregation that occur in stressed cells with deficient proteostasis. These molecular events have been associated with a variety of diseases that are termed as protein misfolding diseases. Protein aggregation is a multiple step process that involves misfolded soluble and insoluble aggregates. It is unclear which of these conformations could lead to cytotoxicity that is associated with diseases. In this seminar, I will describe how we have developed chemical methodologies that allow the community to visualize and differentiate, in live cells, the many conformations through the process of protein aggregation.
Institution: Department of Chemistry, Pennsylvania State University
Hosted by: Professor Benzhong TANG
Abstract
We are fosucsed on protein misfolding and aggregation that occur in stressed cells with deficient proteostasis. These molecular events have been associated with a variety of diseases that are termed as protein misfolding diseases. Protein aggregation is a multiple step process that involves misfolded soluble and insoluble aggregates. It is unclear which of these conformations could lead to cytotoxicity that is associated with diseases. In this seminar, I will describe how we have developed chemical methodologies that allow the community to visualize and differentiate, in live cells, the many conformations through the process of protein aggregation.
8月9日
10:30am - 12:00pm
地點
Room 6602, 6/F (Lifts 31/32), Academic Building, HKUST
講者/表演者
Professor Xin ZHANG
Department of Chemistry, Pennsylvania State University
Department of Chemistry, Pennsylvania State University
主辦單位
Department of Chemistry
聯絡方法
chivy@ust.hk
付款詳情
對象
Faculty and Staff, PG Students
語言
英語
其他活動
11月22日
研討會, 演講, 講座
IAS / School of Science Joint Lecture - Leveraging Protein Dynamics Memory with Machine Learning to Advance Drug Design: From Antibiotics to Targeted Protein Degradation
Abstract
Protein dynamics are fundamental to protein function and encode complex biomolecular mechanisms. Although Markov state models have made it possible to capture long-timescale protein co...
11月8日
研討會, 演講, 講座
IAS / School of Science Joint Lecture - Some Theorems in the Representation Theory of Classical Lie Groups
Abstract
After introducing some basic notions in the representation theory of classical Lie groups, the speaker will explain three results in this theory: the multiplicity one theorem for classical...