8月9日
10:30am - 12:00pm
研讨会, 演讲, 讲座
Speaker: Professor Xin ZHANG
Institution: Department of Chemistry, Pennsylvania State University
Hosted by: Professor Benzhong TANG
Abstract
We are fosucsed on protein misfolding and aggregation that occur in stressed cells with deficient proteostasis. These molecular events have been associated with a variety of diseases that are termed as protein misfolding diseases. Protein aggregation is a multiple step process that involves misfolded soluble and insoluble aggregates. It is unclear which of these conformations could lead to cytotoxicity that is associated with diseases. In this seminar, I will describe how we have developed chemical methodologies that allow the community to visualize and differentiate, in live cells, the many conformations through the process of protein aggregation.
Institution: Department of Chemistry, Pennsylvania State University
Hosted by: Professor Benzhong TANG
Abstract
We are fosucsed on protein misfolding and aggregation that occur in stressed cells with deficient proteostasis. These molecular events have been associated with a variety of diseases that are termed as protein misfolding diseases. Protein aggregation is a multiple step process that involves misfolded soluble and insoluble aggregates. It is unclear which of these conformations could lead to cytotoxicity that is associated with diseases. In this seminar, I will describe how we have developed chemical methodologies that allow the community to visualize and differentiate, in live cells, the many conformations through the process of protein aggregation.
8月9日
10:30am - 12:00pm
地点
Room 6602, 6/F (Lifts 31/32), Academic Building, HKUST
讲者/表演者
Professor Xin ZHANG
Department of Chemistry, Pennsylvania State University
Department of Chemistry, Pennsylvania State University
主办单位
Department of Chemistry
联系方法
chivy@ust.hk
付款详情
对象
Faculty and Staff, PG Students
语言
英语
其他活动
3月24日
研讨会, 演讲, 讲座
IAS / School of Science Joint Lecture - Pushing the Limit of Nonlinear Vibrational Spectroscopy for Molecular Surfaces/Interfaces Studies
Abstract
Surfaces and interfaces are ubiquitous in Nature. Sum-frequency generation vibrational spectroscopy (SFG-VS) is a powerful surface/interface selective and sub-monolayer sensitive spect...
11月22日
研讨会, 演讲, 讲座
IAS / School of Science Joint Lecture - Leveraging Protein Dynamics Memory with Machine Learning to Advance Drug Design: From Antibiotics to Targeted Protein Degradation
Abstract
Protein dynamics are fundamental to protein function and encode complex biomolecular mechanisms. Although Markov state models have made it possible to capture long-timescale protein co...