Division of Life Science
Unravelling Mechanisms of Synaptic Plasticity in Health and Neurodegenerative Diseases
In 2017, this cross-institutional research project led by HKUST was selected as an Area of Excellence (AoE) scheme and awarded HK$63.578 million from the Research Grants Council of Hong Kong for an eight-year period consisting of two phases. This project aims to lay crucial groundwork for delineating the key molecular mechanisms involved in cognitive dysfunction in neurodegenerative diseases such as Alzheimer’s disease. Advancement of this initiative will greatly facilitate the development of new therapeutics that improve the lives of millions of affected patients worldwide, while highlighting Hong Kong’s excellent neuroscience research capacities and infrastructure.
Between 2017 and mid-2020, efforts focused upon the AoE scheme resulted in the publication of 37 scientific papers in high-impact journals, along with 64 invited talks at international conferences and academic institutions. By sharing expertise and insights as well as research technology and materials, team members have established collaborations both locally and internationally, successfully endeavoring novel developments and findings.
Please click here to access the research project homepage.
- President
- The Morningside Professor of Life Science
- Chair Professor, Division of Life Science
- Director of State Key Laboratory of Molecular Neuroscience
科研發現
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科大突破性發現罕見腫瘤細胞「間諜」 揭示不為人知的癌細胞
香港科技大學(科大)研究人員研發了一種可為冷凍和新鮮細胞組織樣本同時進行單細胞DNA和RNA測序的新技術,更利用這方法識別出偽裝為正常細胞的罕見腦腫瘤細胞「間諜」。是次發現為一些最複雜和罕見腫瘤的研究帶來突破,並為未來的藥物靶標發現開闢新方向。
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解構秀麗隱桿線蟲pri-miRNA加工複合體的分子機制
小分子核糖核酸(microRNAs,以下簡稱miRNAs)是一種在動物和人類基因調控中發揮重要作用的小型核糖核酸(RNA),一直令許多科學家為之著迷。在生物學和醫學中,一項非常重要的研究範疇就是miRNA如何控制和調節基因表達,因為科學界一般相信,這個課題對理解細胞突變有重大作用,對於治療癌症和其他與細胞突變有關的疾病,至為關鍵。