Division of Life Science
Unravelling Mechanisms of Synaptic Plasticity in Health and Neurodegenerative Diseases
In 2017, this cross-institutional research project led by HKUST was selected as an Area of Excellence (AoE) scheme and awarded HK$63.578 million from the Research Grants Council of Hong Kong for an eight-year period consisting of two phases. This project aims to lay crucial groundwork for delineating the key molecular mechanisms involved in cognitive dysfunction in neurodegenerative diseases such as Alzheimer’s disease. Advancement of this initiative will greatly facilitate the development of new therapeutics that improve the lives of millions of affected patients worldwide, while highlighting Hong Kong’s excellent neuroscience research capacities and infrastructure.
Between 2017 and mid-2020, efforts focused upon the AoE scheme resulted in the publication of 37 scientific papers in high-impact journals, along with 64 invited talks at international conferences and academic institutions. By sharing expertise and insights as well as research technology and materials, team members have established collaborations both locally and internationally, successfully endeavoring novel developments and findings.
Please click here to access the research project homepage.
- President
- The Morningside Professor of Life Science
- Chair Professor, Division of Life Science
- Director of State Key Laboratory of Molecular Neuroscience
科研发现
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科大突破性发现罕见肿瘤细胞「间谍」 揭示不为人知的癌细胞
香港科技大学(科大)研究人员研发了一种可为冷冻和新鲜细胞组织样本同时进行单细胞DNA和RNA测序的新技术,更利用这方法识别出伪装为正常细胞的罕见脑肿瘤细胞「间谍」。是次发现为一些最复杂和罕见肿瘤的研究带来突破,并为未来的药物靶标发现开辟新方向。
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解构秀丽隐杆线虫pri-miRNA加工复合体的分子机制
小分子核糖核酸(microRNAs,以下简称miRNAs)是一种在动物和人类基因调控中发挥重要作用的小型核糖核酸(RNA),一直令许多科学家为之着迷。在生物学和医学中,一項非常重要的研究范畴就是miRNA如何控制和调节基因表达,因为科学界一般相信,这个课题对理解细胞突变有重大作用,对於治疗癌症和其他与细胞突变有关的疾病,至为关键。