Researchers of the Hong Kong University of Science and Technology (HKUST) recently uncovered a novel molecular mechanism that regulates the subcellular localizations of Arf proteins, shedding light on the mechanism underlying various inherited diseases and offering new insight to the treatment of them.
The small GTPases of the ADP-ribosylation factor (Arf) family are key initiators of various physiological processes including secretion, endocytosis, phagocytosis and signal transduction. Arf family proteins function to mediate recruitment of cytosolic effectors to specific subcellular compartments. This process facilitates Arf effectors to perform cargo recognition, lipid modification or other cellular functions. Read More...
Model demonstrating how arfrp1 and arl14 are recruited to the membranes.
Prof. Guo (first right) and his research team
Researchers at the Hong Kong University of Science and Technology have identified new therapeutic targets for Alzheimer’s disease by studying the patients’ brain with a newly-developed methodology.
Using the theory of local resonance, a research team led by Prof. WEN Weijia from the Department of Physics has found that by crafting a structured pattern of openings...