The polygenic risk score (PRS) derived from the genome-wide association studies (GWASs) predicts the individualized genomic predisposition to complex traits/diseases. Conventional clinical implementations of PRS are constructed from training samples dominated by the European ancestry, hence lose predictive accuracy when applied to minor populations. By modeling the trans-ethnic genetic correlation between Europeans and the target ancestry group, we propose a scalable cross-population analysis framework (XPA) that can effectively harness their shared genetic basis and substantially boost the prediction power in the target population. We apply XPA to analyze a wide range of complex phenotypes, revealing the pervasive existence of genetic basis sharing between Europeans and East Asians. Compared with existing approaches, the PRS constructed by XPA in Chinese population achieves 7.3%-198.0% and 19.5%-313.3% accuracy gain in body height and body mass index (BMI).
14 May 2020
10:00am - 11:00am

Where
https://hkust.zoom.us/j/99688831616
Speakers/Performers
Mr. Mingxuan CAI
HKUST
HKUST
Organizer(S)
Department of Mathematics
Contact/Enquiries
mathseminar@ust.hk
Payment Details
Audience
Alumni, Faculty and Staff, PG Students, UG Students
Language(s)
English
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