A research team from the Hong Kong University of Science and Technology (HKUST) has demonstrated for the first time in-vivo imaging of fine neuronal structures in mouse cortex through the intact skull at an unprecedented depth of 750 µm below pia, making high-resolution microscopy in cortex near non-invasive and measurably facilitating the study of the living brain. Read More...
In vivo 3P calcium imaging of spontaneous neuronal activity at different depths below pia of the somatosensory cortex of a CCK-GCaMP6s mouse (4-month-old) through the intact skull (110-μm thickness) with system correction only (left) and full AO correction (right).
Researchers at the Hong Kong Center for Neurodegenerative Diseases (HKCeND), founded by HKUST, have made promising breakthroughs in early diagnosis and therapeutic treatment of Alzheimer’s disease (AD) that have the potential to transform disease management.
A research led by HKUST has revealed a novel mechanism that regulates secretion of sonic hedgehog (Shh), a key signaling molecular that plays an important role in cancer progression, in mammals, opening the door to novel therapeutic strategies for cancer induced by the hedgehog signaling pathway.